1 The definition of antigen and the chemical characteristics of antigens, The definition of antigen and the chemical characteristics of antigens, haptens and how they become antigenic.
2 The life history of T lymphocytes including their origin, migration to the thymus, and attainment of immunocompetence; forms and effects of negative selection; positive selection and its effect; and dispersal of the naive lymphocyte pool
3 The three pathways of complement activation and the four mechanisms of pathogen destruction aided by complement.
4 Benefits of fever and why the body’s defenses may be compromised by antipyretic drugs.
5 Know the stages of fever
6 Be familiar eith the neutrophil actions of margnination, diapedesis, chemotaxis, phagocytosis and respiratory burst.
7 What an APC does when it detects a foreign antigen; functional differences between MHC-I and MHC-II proteins; how THand TC cells respond to these MHC protein classes
8 Antigen recognition, costimulation, and clonal selection of a T cell; differentiation of selected T cells into effector cells and memory cells
9 How activated TCcells destroy target cells; the roles of interferons, perforin, granzymes, and tumor necrosis factor
10 How an immunocompetent B cell responds when it encounters a foreign antigen; the roles of MHC-II proteins and a THcell in its response, clonal selection of activated B cell and differentiation of memory cells and plasma cells; the difference between a plasma cell and a B cell
11 Know the different characteristics of IgA, IgE, IgE, igG, IgM
12 The pathology of AIDS including the structure of HIV, its mode of action, effect on TH cells, and treatment approaches to HIV (AZT), and diseases that a person is more susceptible to with AIDS (Kaposi Sarcoma)
