Arsenate, AsO43-, acts as a phosphate analog and can replace phosphate in the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) reaction. The product of this reaction is 1-arseno-3-phosphoglycerate. It is unstable and spontaneously hydrolyzes to form 3-phosphoglycerate, as shown below. What is the effect of arsenate on cells undergoing glycolysis?
