Hypertrophic cardiomyopathy(HCM) is a common lethal autosomal dominant heart disease affecting approx 1 in 5000 or more individuals worldwide. The hallwark of this disease is an unusually enlarged (hypertrophic) wall of the left ventricle, which greatly reduces the ventricular volume. In addition, the cardiac muscle cells of the left ventricle are enlarged and disorganized. HCM is responsible for approx 35% of sudden deaths among athletes and is a major cause of sudden death in apparently healthy juveniles and young adults. The HCM phenotype is variable, with the disease showing different outcomes within the same family. A number of gene identification studies have established that HCM is genetically heterogenuous and includes genes that encode for proteins of the thick and think filaments that are specific for cardiac muscle. In order words, HCM is fundamentally a disorder for the cardiac scaromere, the contracile unit bounded by the Z disks. given your extensive knowledge of complex genetic disorders, provide a genetic explanation underlying hc
