The human prion gene is called the PRNP gene Course:- Biology

The human prion gene is called the PRNP gene Course:- Biology

The human prion gene is called the PRNP gene. Fatal familialinsomnia and GSS are inherited prion disease and have mutations inthis gene. Which amino acid differ in the
prion protein made byindividuals that have these two diseases? Why do thesesubstitutions results in the formation of protein aggregates?