Immunodeficiency and Immunotherapy Assignment – Case study –
A 16 month old infant presents with severe disseminated mycobacterial infection, and was previously treated for a Cytomegalovirus infection. The child has fever, sweating and diarrhoea, and abdominal tenderness and lymphadenopathy on examination.
1. What component of the immune system may be defective?
2. Discuss likely diagnoses from the clinical picture.
3. What are the associated pathways involved?
4. Discuss how signalling would normally protect the patient, and how the defect impacts the immune response.
