What drug or pharmaceutical has changed American society more than any?

What drug or pharmaceutical has changed American society more than any?
Which drug has had the biggest positive impact on American society?
Please use the website at Central Intelligence Agency: World Fact Book and discuss the current global status of illicit drugs use in selected of the countries highlighted and explore their drug role/problem further. Choose AUSTRALIA & THE UNITED STATES . Be sure to cite your references. link: https://www.cia.gov/library/publications/resources/the-world-factbook/
Four genetic factors can contribute to drug abuse. Discuss each and give examples of how they might affect the user LINK: https://www.drugabuse.gov/publications/drugfacts/genetics-epigenetics-addiction

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