How might defective mitochondria lead to cancer

Q1. Mutations in the genes that encode certain mitochondrial proteins are associated with a high incidence of some types of cancer. How might defective mitochondria lead to cancer?

Q2. Suppose archaeologists discover human skeletal remains in Ethiopia. Examination of the bones suggests that the remains represent four types of individuals. Two of the skeletons have bone densities that are 30 percent less than those of the other two skeletons. The skeletons with the lower bone mass also have broader front pelvic bones. Within the two groups defined by bone mass, smaller skeletons have bones with evidence of epiphyseal plates, but larger bones have only a thin line where the epiphyseal plates should be. Give the age group and gender of the individuals in the find.

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