Question
Theoretical and experimental measurements show that in many cases, the contributions of ionic and hydrogen-bonding interactions to ?H for protein folding are close to zero. Provide an explanation for this result. (Hint: Consider the environment in which protein folding occurs.)
The formation of favorable ______ ionic or ________ interactions in a _________ protein replace interactions between solvent (water) and the ionic species (or _________donors and acceptors) in the_________ state. The favorable ?H obtained by formation of ____________ bonds in the___________ protein is offset by the energy required to ___________ many interactions, with solvent going from the ________ to the ________ state.
Fill in the blanks above using the words listed below.
H-bonding
H-bond
intermolecular
restore
unfolded
folded
C-bond
break
intramolecular
C-bonding